HSPB8

Gene Information
  • Official Symbol: HSPB8
  • Official Name: heat shock protein family B (small) member 8
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 26353
  • UniProt: Q9UJY1
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008].
  • UniProt Summary: Displays temperature-dependent chaperone activity.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 3403
  • Expression level (log2 read counts): -5.28

Expression Distribution

  • Last modified: 2025/12/10 20:19
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