HSPBP1

Gene Information

Official Symbol: HSPBP1
Official Name: HSPA (Hsp70) binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 23640
UniProt: Q9NZL4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. {ECO:0000269|PubMed:10786638, ECO:0000269|PubMed:12651857, ECO:0000269|PubMed:15215316, ECO:0000269|PubMed:9830037}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7653
Expression level (log2 read counts): 5.02

Expression Distribution

adenyl-nucleotide exchange factor activity
enzyme inhibitor activity
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
positive regulation of protein ubiquitination
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein modification by small protein conjugation or removal
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
regulation of protein ubiquitination
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
regulation of protein modification by small protein conjugation or removal
protein folding
regulation of cellular protein catabolic process
ubiquitin protein ligase binding
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
regulation of proteolysis
negative regulation of catalytic activity
regulation of cellular catabolic process
regulation of catabolic process
endoplasmic reticulum
negative regulation of molecular function
positive regulation of protein modification process
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
regulation of protein modification process