HTR1A

Gene Information

Official Symbol: HTR1A
Official Name: 5-hydroxytryptamine receptor 1A
Aliases and Previous Symbols: N/A
Entrez ID: 3350
UniProt: P08908
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012].
UniProt Summary: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8138923, ECO:0000269|PubMed:8393041}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4290
Expression level (log2 read counts): -7.68

Expression Distribution

7TM GPCR Srsx
7tm 1

adenylate cyclase-inhibiting serotonin receptor signaling pathway
receptor-receptor interaction
regulation of serotonin secretion
serotonin metabolic process
serotonin binding
primary amino compound metabolic process
regulation of catecholamine metabolic process
regulation of dopamine metabolic process
indole-containing compound metabolic process
exploration behavior
behavioral fear response
vasoconstriction
behavioral defense response
fear response
G protein-coupled serotonin receptor activity
G protein-coupled serotonin receptor signaling pathway
neurotransmitter receptor activity
negative regulation of blood vessel diameter
serotonin receptor signaling pathway
multicellular organismal response to stress
regulation of behavior
regulation of cellular amine metabolic process
phenol-containing compound metabolic process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cellular response to dopamine
response to dopamine
neurotransmitter metabolic process
signal transduction involved in cellular response to ammonium ion
cellular response to monoamine stimulus
cellular response to catecholamine stimulus
response to monoamine
response to catecholamine
cellular response to ammonium ion
regulation of tube diameter
regulation of blood vessel diameter
regulation of tube size
regulation of neurotransmitter transport
vascular process in circulatory system
response to ammonium ion
ammonium ion metabolic process