HTR3B

Entrez Summary: The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011].
UniProt Summary: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. {ECO:0000269|PubMed:12867984}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Neur chan LBD
Neur chan memb

serotonin-activated cation-selective channel complex
serotonin-gated cation-selective channel activity
serotonin receptor signaling pathway
extracellular ligand-gated ion channel activity
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to monoamine stimulus
cellular response to catecholamine stimulus
response to monoamine
response to catecholamine
cellular response to ammonium ion
transmembrane signaling receptor activity
response to ammonium ion
postsynaptic membrane
synapse
neuron projection
cellular response to drug
chemical synaptic transmission
anterograde trans-synaptic signaling
regulation of membrane potential
trans-synaptic signaling
synaptic signaling
cellular response to organic cyclic compound
cellular response to organonitrogen compound
cell surface
cellular response to nitrogen compound
response to organic cyclic compound
ion transmembrane transport
response to organonitrogen compound
response to drug
cellular response to oxygen-containing compound
response to nitrogen compound
cell-cell signaling
cellular response to endogenous stimulus
transmembrane transport
ion transport
nervous system process
integral component of plasma membrane
response to endogenous stimulus