HTR6

Entrez Summary: N/A
UniProt Summary: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611). {ECO:0000250|UniProtKB:P31388, ECO:0000250|UniProtKB:Q9R1C8, ECO:0000269|PubMed:23027611}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histamine receptor activity
G protein-coupled serotonin receptor activity
G protein-coupled serotonin receptor signaling pathway
neurotransmitter receptor activity
positive regulation of TOR signaling
serotonin receptor signaling pathway
cerebral cortex cell migration
telencephalon cell migration
forebrain cell migration
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to monoamine stimulus
cellular response to catecholamine stimulus
regulation of TOR signaling
response to catecholamine
response to monoamine
cerebral cortex development
cellular response to ammonium ion
pallium development
response to ammonium ion
cilium
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
telencephalon development
forebrain development
cellular response to drug
anterograde trans-synaptic signaling
dendrite
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
cellular response to organic cyclic compound
cellular response to organonitrogen compound
cellular response to nitrogen compound
G protein-coupled receptor activity
brain development
head development
response to organic cyclic compound
cell migration
central nervous system development