HUWE1 [The Human Chemical-Genetic Interaction Map Project]

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======= HUWE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HUWE1
  * **<color #00a2e8>Official Name</color>**: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10075|10075]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z6Z7|Q7Z6Z7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HUWE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HUWE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300697|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HECT|
|WWE|
|UBA|
|DUF908|
|DUF913|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein targeting to mitochondrion|
|base-excision repair|
|histone ubiquitination|
|regulation of protein targeting to mitochondrion|
|positive regulation of establishment of protein localization to mitochondrion|
|protein monoubiquitination|
|circadian regulation of gene expression|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|positive regulation of protein ubiquitination|
|positive regulation of mitochondrion organization|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|positive regulation of protein modification by small protein conjugation or removal|
|circadian rhythm|
|positive regulation of intracellular protein transport|
|regulation of mitochondrion organization|
|regulation of protein ubiquitination|
|positive regulation of intracellular transport|
|ubiquitin protein ligase activity|
|regulation of protein modification by small protein conjugation or removal|
|regulation of intracellular protein transport|
|ubiquitin-protein transferase activity|
|rhythmic process|
|protein polyubiquitination|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|histone modification|
|covalent chromatin modification|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|DNA repair|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|protein catabolic process|
|protein ubiquitination|
|chromatin organization|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|leukocyte mediated immunity|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|exocytosis|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|leukocyte activation|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|proteolysis|
|regulation of organelle organization|
|RNA binding|
|DNA binding|
|positive regulation of cellular protein metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 524/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|24/26|
|bone|18/25|
|breast|22/30|
|central nervous system|36/49|
|cervix|2/4|
|colorectal|14/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|9/14|
|kidney|18/18|
|liver|12/19|
|lung|53/72|
|lymphocyte|10/14|
|ovary|18/25|
|pancreas|18/22|
|peripheral nervous system|12/15|
|plasma cell|10/12|
|prostate|1/1|
|skin|17/20|
|soft tissue|5/7|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|17/28|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 573
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HUWE1 Expression in NALM6 Cells: 9.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>