HUWE1

Gene Information

Official Symbol: HUWE1
Official Name: HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
Aliases and Previous Symbols: N/A
Entrez ID: 10075
UniProt: Q7Z6Z7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 524/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	19/28
blood	24/26
bone	18/25
breast	22/30
central nervous system	36/49
cervix	2/4
colorectal	14/17
esophagus	11/11
fibroblast	1/1
gastric	9/14
kidney	18/18
liver	12/19
lung	53/72
lymphocyte	10/14
ovary	18/25
pancreas	18/22
peripheral nervous system	12/15
plasma cell	10/12
prostate	1/1
skin	17/20
soft tissue	5/7
thyroid	2/2
upper aerodigestive	19/22
urinary tract	17/28
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 573
Expression level (log2 read counts): 9.27

Expression Distribution

HECT
WWE
UBA
DUF908
DUF913

positive regulation of protein targeting to mitochondrion
base-excision repair
histone ubiquitination
regulation of protein targeting to mitochondrion
positive regulation of establishment of protein localization to mitochondrion
protein monoubiquitination
circadian regulation of gene expression
regulation of establishment of protein localization to mitochondrion
regulation of protein targeting
positive regulation of protein ubiquitination
positive regulation of mitochondrion organization
secretory granule lumen
ficolin-1-rich granule lumen
positive regulation of protein modification by small protein conjugation or removal
circadian rhythm
positive regulation of intracellular protein transport
regulation of mitochondrion organization
regulation of protein ubiquitination
positive regulation of intracellular transport
ubiquitin protein ligase activity
regulation of protein modification by small protein conjugation or removal
regulation of intracellular protein transport
ubiquitin-protein transferase activity
rhythmic process
protein polyubiquitination
positive regulation of cellular protein localization
regulation of intracellular transport
histone modification
covalent chromatin modification
positive regulation of protein transport
positive regulation of establishment of protein localization
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
DNA repair
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response