HYOU1

Gene Information

Official Symbol: HYOU1
Official Name: hypoxia up-regulated 1
Aliases and Previous Symbols: N/A
Entrez ID: 10525
UniProt: Q9Y4L1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. {ECO:0000269|PubMed:10037731}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MS023 7μM R03 exp135	-1.99
Trametinib 10μM R02 exp83	-1.83
HMS-I1 10μM R06 exp256	1.72
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.78
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.84

Global Fraction of Cell Lines Where Essential: 698/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	25/28
bone	26/26
breast	26/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	14/16
kidney	20/21
liver	19/20
lung	69/75
lymphocyte	15/16
ovary	24/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	27/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 253
Expression level (log2 read counts): 9.17

Expression Distribution

negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of cellular response to hypoxia
endoplasmic reticulum chaperone complex
regulation of cellular response to hypoxia
endocytic vesicle lumen
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
smooth endoplasmic reticulum
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of response to endoplasmic reticulum stress
response to ischemia
IRE1-mediated unfolded protein response
regulation of response to endoplasmic reticulum stress
negative regulation of intrinsic apoptotic signaling pathway
chaperone binding
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
negative regulation of neuron apoptotic process
cellular response to topologically incorrect protein
regulation of intrinsic apoptotic signaling pathway
response to unfolded protein
response to topologically incorrect protein
cellular response to hypoxia
cellular response to decreased oxygen levels
regulation of neuron apoptotic process
negative regulation of neuron death
endoplasmic reticulum to Golgi vesicle-mediated transport
cellular response to oxygen levels
negative regulation of apoptotic signaling pathway
receptor-mediated endocytosis
response to endoplasmic reticulum stress
endoplasmic reticulum lumen
regulation of neuron death
response to hypoxia
response to decreased oxygen levels
Golgi vesicle transport
response to oxygen levels
regulation of apoptotic signaling pathway