IARS [The Human Chemical-Genetic Interaction Map Project]

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======= IARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IARS1
  * **<color #00a2e8>Official Name</color>**: isoleucyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3376|3376]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41252|P41252]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600709|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Anticodon 1|
|tRNA-synt 1|
|tRNA-synt 1g|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|isoleucine-tRNA ligase activity|
|isoleucyl-tRNA aminoacylation|
|aminoacyl-tRNA synthetase multienzyme complex|
|aminoacyl-tRNA editing activity|
|aminoacyl-tRNA metabolism involved in translational fidelity|
|regulation of translational fidelity|
|GTPase binding|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|osteoblast differentiation|
|tRNA metabolic process|
|ossification|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.76|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.7|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.73|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.75|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.79|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.97|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.05|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.54|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.598|
|[[:human genes:m:mars|MARS]]|0.448|
|[[:human genes:m:meaf6|MEAF6]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 709/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|26/26|
|breast|30/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|19/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 247
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IARS Expression in NALM6 Cells: 9.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>