IARS

Entrez Summary: N/A
UniProt Summary: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.76
Mubritinib 0.2μM R02 exp65	-1.7
RO-3306 3 to 4μM on day4 R04 exp165	1.73
CHIR-124 0.04μM R06 exp272	1.75
Pimelic-diphenylamide-106 5μM R00 exp28	1.79
Etoposide 1μM R00 exp19	1.97
UM0129480 7μM R02 exp85	2.05
Actinomycin-D 0.001μM R00 exp3	2.54
5-Fluorouracil 20μM R00 exp2	2.6

Global Fraction of Cell Lines Where Essential: 709/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	28/28
bone	26/26
breast	30/33
central nervous system	55/56
cervix	4/4
colorectal	16/17
esophagus	11/13
fibroblast	1/1
gastric	16/16
kidney	19/21
liver	20/20
lung	73/75
lymphocyte	15/16
ovary	26/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	14/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	29/29
uterus	5/5

Expression Distribution

isoleucine-tRNA ligase activity
isoleucyl-tRNA aminoacylation
aminoacyl-tRNA synthetase multienzyme complex
aminoacyl-tRNA editing activity
aminoacyl-tRNA metabolism involved in translational fidelity
regulation of translational fidelity
GTPase binding
tRNA aminoacylation for protein translation
tRNA aminoacylation
amino acid activation
tRNA binding
osteoblast differentiation
tRNA metabolic process
ossification
cellular amino acid metabolic process
translation
peptide biosynthetic process
ncRNA metabolic process
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
membrane
gene expression