IDH3G

Official Symbol: IDH3G
Official Name: isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
Aliases and Previous Symbols: N/A
Entrez ID: 3421
UniProt: P51553
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. {ECO:0000269|PubMed:28139779}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

isocitrate dehydrogenase (NAD+) activity
isocitrate metabolic process
tricarboxylic acid metabolic process
tricarboxylic acid cycle
NAD binding
aerobic respiration
secondary alcohol metabolic process
cellular respiration
magnesium ion binding
energy derivation by oxidation of organic compounds
alcohol metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
organic hydroxy compound metabolic process
carbohydrate metabolic process
nucleolus
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
mitochondrion
ATP binding
small molecule metabolic process