IDUA

Entrez Summary: This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

L-iduronidase activity
heparin catabolic process
dermatan sulfate catabolic process
coated vesicle
heparin metabolic process
disaccharide metabolic process
dermatan sulfate metabolic process
chondroitin sulfate catabolic process
dermatan sulfate proteoglycan metabolic process
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan metabolic process
oligosaccharide metabolic process
sulfur compound catabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
proteoglycan metabolic process
lysosomal lumen
mucopolysaccharide metabolic process
monocarboxylic acid catabolic process
drug catabolic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
carbohydrate derivative catabolic process
carboxylic acid catabolic process
organic acid catabolic process
signaling receptor binding
sulfur compound metabolic process
glycoprotein metabolic process
small molecule catabolic process
carbohydrate metabolic process
drug metabolic process
monocarboxylic acid metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
small molecule metabolic process