IFITM3 [The Human Chemical-Genetic Interaction Map Project]

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======= IFITM3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IFITM3
  * **<color #00a2e8>Official Name</color>**: interferon induced transmembrane protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10410|10410]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01628|Q01628]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IFITM3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IFITM3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605579|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. {ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22046135, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:23601107}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CD225|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of viral entry into host cell|
|response to interferon-alpha|
|negative regulation of viral transcription|
|response to interferon-beta|
|regulation of viral entry into host cell|
|negative regulation of viral genome replication|
|regulation of viral transcription|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|response to type I interferon|
|negative regulation of viral life cycle|
|regulation of viral genome replication|
|negative regulation of viral process|
|late endosome membrane|
|regulation of viral life cycle|
|response to interferon-gamma|
|defense response to virus|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|response to virus|
|lysosomal membrane|
|protein-containing complex|
|cytokine-mediated signaling pathway|
|innate immune response|
|regulation of multi-organism process|
|defense response to other organism|
|cellular response to cytokine stimulus|
|immune effector process|
|response to cytokine|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.91|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.86|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.74|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 246/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|12/28|
|bone|10/26|
|breast|11/33|
|central nervous system|27/56|
|cervix|2/4|
|colorectal|10/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|2/21|
|liver|4/20|
|lung|28/75|
|lymphocyte|5/16|
|ovary|7/26|
|pancreas|7/24|
|peripheral nervous system|9/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|7/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4048
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IFITM3 Expression in NALM6 Cells: 0.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>