IFITM3

Gene Information

Official Symbol: IFITM3
Official Name: interferon induced transmembrane protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 10410
UniProt: Q01628
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012].
UniProt Summary: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. {ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22046135, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:23601107}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 246/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	12/28
bone	10/26
breast	11/33
central nervous system	27/56
cervix	2/4
colorectal	10/17
esophagus	3/13
fibroblast	0/1
gastric	5/16
kidney	2/21
liver	4/20
lung	28/75
lymphocyte	5/16
ovary	7/26
pancreas	7/24
peripheral nervous system	9/16
plasma cell	9/15
prostate	1/1
skin	6/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	6/22
urinary tract	7/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 4048
Expression level (log2 read counts): 0.9

Expression Distribution

Screen	Score
YM155 0.0002μM R01 exp61	-1.91
RO-3307 4.7μM R02 exp80	-1.86
Dynasore 10μM R04 exp180	-1.74
TIC10 10μM R08 exp532	-1.71

negative regulation of viral entry into host cell
response to interferon-alpha
negative regulation of viral transcription
response to interferon-beta
regulation of viral entry into host cell
negative regulation of viral genome replication
regulation of viral transcription
cellular response to type I interferon
type I interferon signaling pathway
response to type I interferon
negative regulation of viral life cycle
regulation of viral genome replication
negative regulation of viral process
late endosome membrane
regulation of viral life cycle
response to interferon-gamma
defense response to virus
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
response to virus
lysosomal membrane
protein-containing complex
cytokine-mediated signaling pathway
innate immune response
regulation of multi-organism process
defense response to other organism
cellular response to cytokine stimulus
immune effector process
response to cytokine
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
immune response