IFNA21

Entrez Summary: This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011].
UniProt Summary: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. {ECO:0000269|PubMed:1634550}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cytokine receptor binding
type I interferon receptor binding
positive regulation of peptidyl-serine phosphorylation of STAT protein
regulation of peptidyl-serine phosphorylation of STAT protein
natural killer cell activation involved in immune response
B cell proliferation
response to exogenous dsRNA
response to dsRNA
natural killer cell activation
T cell activation involved in immune response
cellular response to type I interferon
type I interferon signaling pathway
response to type I interferon
lymphocyte proliferation
mononuclear cell proliferation
leukocyte proliferation
positive regulation of peptidyl-serine phosphorylation
B cell differentiation
lymphocyte activation involved in immune response
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
regulation of peptidyl-serine phosphorylation
B cell activation
cytokine activity
defense response to virus
T cell activation
lymphocyte differentiation
response to virus
blood coagulation
coagulation
hemostasis
leukocyte differentiation
humoral immune response
lymphocyte activation
wound healing
regulation of body fluid levels
cell population proliferation
hemopoiesis
response to wounding
hematopoietic or lymphoid organ development