IFNG
Gene Information
- Official Symbol: IFNG
- Official Name: interferon gamma
- Aliases and Previous Symbols: N/A
- Entrez ID: 3458
- UniProt: P01579
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].
- UniProt Summary: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Pfam Domains GO Terms
Pfam Domains
| IFN-gamma |
GO Terms
| interferon-gamma receptor binding |
| positive regulation of fructose 1,6-bisphosphate metabolic process |
| regulation of carbohydrate phosphatase activity |
| regulation of fructose 1,6-bisphosphate 1-phosphatase activity |
| regulation of fructose 1,6-bisphosphate metabolic process |
| positive regulation of iron ion transmembrane transport |
| positive regulation of iron ion transport |
| positive regulation of iron ion import across plasma membrane |
| positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity |
| positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response |
| positive regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response |
| regulation of iron ion import across plasma membrane |
| positive regulation of calcidiol 1-monooxygenase activity |
| regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation |
| negative regulation of tau-protein kinase activity |
| positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation |
| positive regulation of vitamin D biosynthetic process |
| regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| regulation of iron ion transmembrane transport |
| positive regulation of vitamin metabolic process |
| positive regulation of interleukin-23 production |
| positive regulation of NMDA glutamate receptor activity |
| positive regulation of core promoter binding |
| positive regulation of interleukin-1 biosynthetic process |
| regulation of interleukin-1 biosynthetic process |
| regulation of iron ion transport |
| regulation of calcidiol 1-monooxygenase activity |
| positive regulation of interleukin-1 beta biosynthetic process |
| regulation of interleukin-1 beta biosynthetic process |
| regulation of core promoter binding |
| regulation of interleukin-23 production |
| negative regulation of amyloid-beta clearance |
| regulation of vitamin D biosynthetic process |
| positive regulation of cellular respiration |
| positive regulation of MHC class II biosynthetic process |
| regulation of protein ADP-ribosylation |
| regulation of tau-protein kinase activity |
| positive regulation of hormone biosynthetic process |
| positive regulation of chemokine biosynthetic process |
| positive regulation of receptor biosynthetic process |
| regulation of vitamin metabolic process |
| regulation of MHC class II biosynthetic process |
| positive regulation of killing of cells of other organism |
| positive regulation of regulatory T cell differentiation |
| negative regulation of interleukin-17 production |
| positive regulation of smooth muscle cell apoptotic process |
| positive regulation of amyloid-beta formation |
| positive regulation of exosomal secretion |
| regulation of chemokine biosynthetic process |
| positive regulation of nitric-oxide synthase biosynthetic process |
| positive regulation of membrane protein ectodomain proteolysis |
| positive regulation of hormone metabolic process |
| regulation of amyloid-beta clearance |
| positive regulation of glutamate receptor signaling pathway |
| regulation of killing of cells of other organism |
| positive regulation of steroid biosynthetic process |
| regulation of exosomal secretion |
| regulation of nitric-oxide synthase biosynthetic process |
| positive regulation of amyloid precursor protein catabolic process |
| astrocyte activation |
| positive regulation of peptidyl-serine phosphorylation of STAT protein |
| positive regulation of tumor necrosis factor secretion |
| positive regulation of tumor necrosis factor biosynthetic process |
| regulation of peptidyl-serine phosphorylation of STAT protein |
| positive regulation of protein deacetylation |
| regulation of membrane protein ectodomain proteolysis |
| positive regulation of glycolytic process |
| regulation of receptor biosynthetic process |
| regulation of smooth muscle cell apoptotic process |
| regulation of response to interferon-gamma |
| regulation of interferon-gamma-mediated signaling pathway |
| positive regulation of alcohol biosynthetic process |
| positive regulation of transcription regulatory region DNA binding |
| positive regulation of osteoclast differentiation |
| positive regulation of monooxygenase activity |
| positive regulation of steroid metabolic process |
| regulation of amyloid-beta formation |
| regulation of hormone biosynthetic process |
| positive regulation of muscle cell apoptotic process |
| regulation of tumor necrosis factor secretion |
| regulation of interleukin-17 production |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of regulatory T cell differentiation |
| microglial cell activation |
| regulation of tumor necrosis factor biosynthetic process |
| regulation of cellular respiration |
| leukocyte activation involved in inflammatory response |
| regulation of amyloid precursor protein catabolic process |
| positive regulation of phosphatase activity |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of signaling receptor activity |
| positive regulation of interleukin-12 production |
| astrocyte development |
| regulation of NMDA receptor activity |
| positive regulation of protein import into nucleus |
| glial cell activation |
| regulation of hormone metabolic process |
| receptor signaling pathway via JAK-STAT |
| positive regulation of protein import |
| receptor signaling pathway via STAT |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of nitric oxide metabolic process |
| neuroinflammatory response |
| negative regulation of epithelial cell differentiation |
| regulation of protein deacetylation |
| positive regulation of purine nucleotide metabolic process |
| positive regulation of nucleotide metabolic process |
| positive regulation of ATP metabolic process |
| negative regulation of smooth muscle cell proliferation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of alpha-beta T cell differentiation |
| interleukin-12-mediated signaling pathway |
| cellular response to interleukin-12 |
| response to interleukin-12 |
| positive regulation of reactive oxygen species biosynthetic process |
| macrophage activation |
| positive regulation of interleukin-1 beta production |
| regulation of transcription regulatory region DNA binding |
| positive regulation of oxidoreductase activity |
| astrocyte differentiation |
| regulation of interleukin-12 production |
| regulation of monooxygenase activity |
| regulation of protein import into nucleus |
| positive regulation of protein localization to plasma membrane |
| positive regulation of myeloid leukocyte differentiation |
| positive regulation of DNA binding |
| regulation of nitric oxide biosynthetic process |
| positive regulation of chemokine production |
| regulation of protein import |
| positive regulation of interleukin-1 production |
| positive regulation of dephosphorylation |
| regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| positive regulation of protein localization to cell periphery |
| positive regulation of nucleocytoplasmic transport |
| regulation of glutamate receptor signaling pathway |
| regulation of osteoclast differentiation |
| positive regulation of cell killing |
| positive regulation of cytokine biosynthetic process |
| positive regulation of tyrosine phosphorylation of STAT protein |
| regulation of muscle cell apoptotic process |
| positive regulation of phagocytosis |
| positive regulation of cation channel activity |
| interferon-gamma-mediated signaling pathway |
| regulation of neurotransmitter receptor activity |
| regulation of alcohol biosynthetic process |
| positive regulation of protein localization to nucleus |
| regulation of chemokine production |
| regulation of glycolytic process |
| positive regulation of carbohydrate metabolic process |
| regulation of tyrosine phosphorylation of STAT protein |
| positive regulation of lipid biosynthetic process |
| regulation of interleukin-1 beta production |
| positive regulation of T cell differentiation |
| positive regulation of receptor signaling pathway via JAK-STAT |
| regulation of reactive oxygen species biosynthetic process |
| positive regulation of tumor necrosis factor production |
| positive regulation of receptor signaling pathway via STAT |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| regulation of steroid biosynthetic process |
| regulation of carbohydrate catabolic process |
| positive regulation of exocytosis |
| positive regulation of myeloid cell differentiation |
| positive regulation of neuron death |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| regulation of interleukin-1 production |
| regulation of protein localization to plasma membrane |
| regulation of oxidoreductase activity |
| positive regulation of reactive oxygen species metabolic process |
| regulation of phagocytosis |
| extrinsic apoptotic signaling pathway |
| regulation of cell killing |
| positive regulation of ion transmembrane transporter activity |
| regulation of cytokine biosynthetic process |
| positive regulation of peptidyl-serine phosphorylation |
| regulation of nucleocytoplasmic transport |
| glial cell development |
| positive regulation of transporter activity |
| regulation of steroid metabolic process |
| regulation of protein localization to cell periphery |
| regulation of myeloid leukocyte differentiation |
| regulation of purine nucleotide metabolic process |
| regulation of protein localization to nucleus |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| positive regulation of autophagy |
| positive regulation of protein localization to membrane |
| regulation of DNA binding |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of smooth muscle cell proliferation |
| regulation of receptor signaling pathway via STAT |
| regulation of peptidyl-serine phosphorylation |
| regulation of T cell differentiation |
| positive regulation of small molecule metabolic process |
| positive regulation of cytokine secretion |
| positive regulation of epithelial cell migration |
| positive regulation of cation transmembrane transport |
| regulation of epithelial cell differentiation |
| positive regulation of lipid metabolic process |
| cell cycle arrest |
| positive regulation of leukocyte differentiation |
| regulation of tumor necrosis factor production |
| positive regulation of cellular amide metabolic process |
| regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of intracellular protein transport |
| positive regulation of ion transmembrane transport |
| regulation of generation of precursor metabolites and energy |
| cellular response to interferon-gamma |
| regulation of cytokine-mediated signaling pathway |
| regulation of lymphocyte differentiation |
| glial cell differentiation |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| cytokine activity |
| regulation of response to cytokine stimulus |
| regulation of phosphatase activity |
| regulation of insulin secretion |
| positive regulation of binding |
| regulation of reactive oxygen species metabolic process |
| response to interferon-gamma |
| regulation of lipid biosynthetic process |
| positive regulation of hemopoiesis |
| regulation of protein localization to membrane |
| positive regulation of peptidyl-tyrosine phosphorylation |
| defense response to virus |
| positive regulation of transmembrane transport |
| positive regulation of T cell activation |
| regulation of carbohydrate metabolic process |
| regulation of cytokine secretion |
| positive regulation of intracellular transport |
| regulation of peptide hormone secretion |
| regulation of dephosphorylation |
| gliogenesis |
| positive regulation of protein catabolic process |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of epithelial cell migration |
| regulation of exocytosis |
| negative regulation of protein kinase activity |
| regulation of myeloid cell differentiation |
| regulation of intracellular protein transport |
| negative regulation of kinase activity |
| positive regulation of protein complex assembly |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| positive regulation of ion transport |
| negative regulation of transferase activity |
| regulation of transporter activity |
| response to virus |
| apoptotic signaling pathway |
| positive regulation of peptide secretion |
| regulation of leukocyte cell-cell adhesion |
| regulation of neuron death |
| regulation of T cell activation |
| positive regulation of cellular protein localization |
| regulation of autophagy |
| regulation of cation transmembrane transport |
| positive regulation of protein serine/threonine kinase activity |
| humoral immune response |
| regulation of intracellular transport |
| regulation of neurotransmitter levels |
| positive regulation of proteolysis |
| positive regulation of lymphocyte activation |
| positive regulation of cellular catabolic process |
| regulation of binding |
| regulation of protein catabolic process |
| regulation of metal ion transport |
| regulation of lipid metabolic process |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of secretion by cell |
| positive regulation of cell adhesion |
| regulation of cellular amide metabolic process |
| negative regulation of protein phosphorylation |
| positive regulation of cell activation |
| positive regulation of protein transport |
| regulation of small molecule metabolic process |
| positive regulation of catabolic process |
| positive regulation of secretion |
| negative regulation of phosphorylation |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of protein complex assembly |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of neurogenesis |
| regulation of ion transmembrane transport |
| regulation of peptide secretion |
| inflammatory response |
| positive regulation of cell migration |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cellular component biogenesis |
| regulation of response to biotic stimulus |
| positive regulation of cell motility |
| regulation of hormone levels |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| positive regulation of cell development |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| negative regulation of protein modification process |
| regulation of leukocyte activation |
| adaptive immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| regulation of growth |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of ion transport |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of proteolysis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| innate immune response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of neurogenesis |
| regulation of cellular catabolic process |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| regulation of kinase activity |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| apoptotic process |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| negative regulation of developmental process |
| defense response to other organism |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| regulation of catabolic process |
| cell cycle process |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| positive regulation of phosphorylation |
| cell activation |
| cell death |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| cell cycle |
| defense response |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cycloheximide 0.2μM R00 exp15 | 1.73 |
| Nocodazole 0.02μM R00 exp23 | 1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14978
- Expression level (log2 read counts): -7.68
Expression Distribution
IFNG Expression in NALM6 Cells: -7.68
