IFNGR1

Gene Information

Official Symbol: IFNGR1
Official Name: interferon gamma receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 3459
UniProt: P15260
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008].
UniProt Summary: Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550). {ECO:0000269|PubMed:10986460, ECO:0000269|PubMed:20015550, ECO:0000269|PubMed:2971451, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7617032, ECO:0000269|PubMed:7673114}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8364
Expression level (log2 read counts): 5.73

Expression Distribution

Screen	Score
MS023 7μM R03 exp135	-1.79
PU-H71 1μM R08 exp515	-1.78

Tissue fac
IFNGR1
Interfer-bind

interferon-gamma receptor activity
negative regulation of amyloid-beta clearance
positive regulation of amyloid-beta formation
regulation of amyloid-beta clearance
positive regulation of amyloid precursor protein catabolic process
astrocyte activation
positive regulation of tumor necrosis factor secretion
regulation of interferon-gamma-mediated signaling pathway
regulation of response to interferon-gamma
regulation of amyloid-beta formation
regulation of tumor necrosis factor secretion
microglial cell activation
leukocyte activation involved in inflammatory response
regulation of amyloid precursor protein catabolic process
astrocyte development
glial cell activation
cytokine binding
neuroinflammatory response
cytokine receptor activity
macrophage activation
astrocyte differentiation
interferon-gamma-mediated signaling pathway
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
glial cell development
positive regulation of cytokine secretion
regulation of tumor necrosis factor production
positive regulation of cellular amide metabolic process
regulation of tumor necrosis factor superfamily cytokine production
cellular response to interferon-gamma
regulation of cytokine-mediated signaling pathway
glial cell differentiation
regulation of response to cytokine stimulus
response to interferon-gamma
regulation of cytokine secretion
gliogenesis
positive regulation of protein secretion
response to virus
positive regulation of peptide secretion
regulation of cellular amide metabolic process