IFNK

Entrez Summary: N/A
UniProt Summary: May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. {ECO:0000269|PubMed:11514542, ECO:0000269|PubMed:12391192}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

type I interferon receptor binding
positive regulation of peptidyl-serine phosphorylation of STAT protein
regulation of peptidyl-serine phosphorylation of STAT protein
natural killer cell activation involved in immune response
B cell proliferation
response to exogenous dsRNA
response to dsRNA
natural killer cell activation
T cell activation involved in immune response
lymphocyte proliferation
mononuclear cell proliferation
leukocyte proliferation
positive regulation of peptidyl-serine phosphorylation
B cell differentiation
lymphocyte activation involved in immune response
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
regulation of peptidyl-serine phosphorylation
B cell activation
cytokine activity
defense response to virus
T cell activation
lymphocyte differentiation
response to virus
leukocyte differentiation
positive regulation of innate immune response
humoral immune response
positive regulation of response to biotic stimulus
lymphocyte activation
regulation of innate immune response
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
cell population proliferation
hemopoiesis
positive regulation of response to external stimulus
hematopoietic or lymphoid organ development
adaptive immune response
leukocyte activation involved in immune response
cell activation involved in immune response