IFRD1

Entrez Summary: This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010].
UniProt Summary: Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bortezomib 0.005μM R00 exp6	1.91
Cycloheximide 0.2μM R00 exp15	1.93

IFRD
IFRD C

myoblast fate determination
myoblast fate commitment
negative regulation of collateral sprouting
regulation of collateral sprouting
skeletal muscle tissue regeneration
myoblast differentiation
cell fate determination
negative regulation of axon extension
tissue regeneration
negative regulation of axonogenesis
regulation of axon extension
negative regulation of cell morphogenesis involved in differentiation
negative regulation of developmental growth
regulation of extent of cell growth
negative regulation of neuron projection development
regeneration
regulation of cell size
negative regulation of cell projection organization
negative regulation of cell growth
regulation of axonogenesis
negative regulation of neuron differentiation
negative regulation of growth
muscle cell differentiation
cell fate commitment
striated muscle tissue development
negative regulation of neurogenesis
muscle tissue development
regulation of cell morphogenesis involved in differentiation
negative regulation of nervous system development
regulation of developmental growth
negative regulation of cell development
regulation of cellular component size
developmental growth
growth
regulation of cell growth
muscle structure development
wound healing
regulation of cell morphogenesis
regulation of neuron projection development
regulation of anatomical structure size