IFT27

Entrez Summary: This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
UniProt Summary: Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25 (By similarity). {ECO:0000250|UniProtKB:A8HN58, ECO:0000269|PubMed:25443296}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.89
Nicotinate 1000μM R03 exp140	2.19

Miro
Ras

intraciliary transport particle B
sperm midpiece
sperm principal piece
inner ear receptor cell stereocilium organization
intraciliary transport involved in cilium assembly
inner ear receptor cell development
sperm flagellum
ciliary tip
cochlea development
inner ear receptor cell differentiation
intraciliary transport
mechanoreceptor differentiation
microtubule-based protein transport
protein transport along microtubule
Rab protein signal transduction
smoothened signaling pathway
motile cilium
transport along microtubule
cytoskeleton-dependent intracellular transport
microtubule-based transport
inner ear development
cilium
ear development
Ras protein signal transduction
protein-containing complex localization
kidney development
microtubule-based movement
renal system development
urogenital system development
small GTPase mediated signal transduction
GTPase activity
cilium assembly
cilium organization
GTP binding
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
spermatogenesis
sensory organ development
male gamete generation