IFT52

Entrez Summary: This gene encodes a conserved proline-rich protein that is a component of the intraflagellar transport-B (IFT-B) core complex. The encoded protein is essential for the integrity of the IFT-B core complex, and for biosynthesis and maintenance of cilia. Mutations in this gene are associated with ciliopathy that affects the skeleton. [provided by RefSeq, Oct 2016].
UniProt Summary: Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia (PubMed:27466190). Required for the anterograde transport of IFT88 (PubMed:27466190). {ECO:0000269|PubMed:27466190}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intraciliary anterograde transport
dendrite terminus
intraciliary transport particle B
ciliary base
photoreceptor connecting cilium
intraciliary transport involved in cilium assembly
non-motile cilium assembly
ciliary tip
intraciliary transport
heart looping
embryonic digit morphogenesis
embryonic heart tube morphogenesis
regulation of protein processing
determination of heart left/right asymmetry
microtubule-based protein transport
protein transport along microtubule
regulation of protein maturation
smoothened signaling pathway
embryonic heart tube development
dorsal/ventral pattern formation
motile cilium
neural tube formation
determination of left/right symmetry
embryonic epithelial tube formation
determination of bilateral symmetry
negative regulation of epithelial cell proliferation
specification of symmetry
embryonic limb morphogenesis
embryonic appendage morphogenesis
epithelial tube formation
ciliary basal body
centriole
morphogenesis of embryonic epithelium
tube formation
limb morphogenesis
appendage morphogenesis
transport along microtubule
neural tube development
cytoskeleton-dependent intracellular transport
appendage development