IFT80

Entrez Summary: The protein encoded by this gene is part of the intraflagellar transport complex B and is necessary for the function of motile and sensory cilia. Defects in this gene are a cause of asphyxiating thoracic dystrophy 2 (ATD2). Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Jun 2010].
UniProt Summary: Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. {ECO:0000269|PubMed:17468754}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of non-canonical Wnt signaling pathway
intraciliary transport particle B
regulation of non-canonical Wnt signaling pathway
intraciliary transport involved in cilium assembly
ciliary tip
non-motile cilium assembly
intraciliary transport
microtubule-based protein transport
protein transport along microtubule
smoothened signaling pathway
chondrocyte differentiation
bone morphogenesis
negative regulation of epithelial cell proliferation
osteoblast differentiation
transport along microtubule
cartilage development
cytoskeleton-dependent intracellular transport
microtubule-based transport
cilium
bone development
negative regulation of Wnt signaling pathway
connective tissue development
skeletal system morphogenesis
protein-containing complex localization
ossification
microtubule-based movement
regulation of epithelial cell proliferation
cilium assembly
regulation of Wnt signaling pathway
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
skeletal system development
microtubule-based process
negative regulation of cell population proliferation
organelle assembly
animal organ morphogenesis
intracellular protein transport
plasma membrane bounded cell projection organization