IGF1
Gene Information
- Official Symbol: IGF1
- Official Name: insulin like growth factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3479
- UniProt: P05019
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015].
- UniProt Summary: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down- stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23696648, PubMed:23243309). {ECO:0000250|UniProtKB:P05017, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:21076856, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:23243309, ECO:0000269|PubMed:23696648, ECO:0000269|PubMed:24132240}.
Pfam Domains GO Terms
Pfam Domains
| Insulin |
GO Terms
| positive regulation of trophectodermal cell proliferation |
| regulation of trophectodermal cell proliferation |
| negative regulation of vascular associated smooth muscle cell apoptotic process |
| insulin-like growth factor binding protein complex |
| glycolate metabolic process |
| negative regulation of oocyte development |
| skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration |
| insulin-like growth factor ternary complex |
| alphav-beta3 integrin-IGF-1-IGF1R complex |
| negative regulation of oogenesis |
| myoblast proliferation |
| bone mineralization involved in bone maturation |
| negative regulation of smooth muscle cell apoptotic process |
| positive regulation of cell growth involved in cardiac muscle cell development |
| regulation of vascular associated smooth muscle cell apoptotic process |
| regulation of oocyte development |
| regulation of oogenesis |
| negative regulation of neuroinflammatory response |
| positive regulation of insulin-like growth factor receptor signaling pathway |
| negative regulation of amyloid-beta formation |
| insulin-like growth factor receptor signaling pathway |
| ossification involved in bone maturation |
| negative regulation of amyloid precursor protein catabolic process |
| positive regulation of calcineurin-NFAT signaling cascade |
| insulin-like growth factor receptor binding |
| positive regulation of calcineurin-mediated signaling |
| positive regulation of glycogen biosynthetic process |
| bone maturation |
| regulation of cell growth involved in cardiac muscle cell development |
| positive regulation of glycogen metabolic process |
| positive regulation of cardiac muscle cell differentiation |
| negative regulation of release of cytochrome c from mitochondria |
| positive regulation of glycoprotein biosynthetic process |
| animal organ maturation |
| insulin receptor binding |
| positive regulation of activated T cell proliferation |
| positive regulation of glycoprotein metabolic process |
| regulation of insulin-like growth factor receptor signaling pathway |
| positive regulation of glycolytic process |
| regulation of smooth muscle cell apoptotic process |
| positive regulation of transcription regulatory region DNA binding |
| exocytic vesicle |
| myotube cell development |
| regulation of amyloid-beta formation |
| negative regulation of interleukin-1 beta production |
| positive regulation of cardiocyte differentiation |
| ERK1 and ERK2 cascade |
| regulation of glycogen biosynthetic process |
| regulation of glucan biosynthetic process |
| positive regulation of cardiac muscle hypertrophy |
| positive regulation of muscle hypertrophy |
| regulation of neuroinflammatory response |
| muscle hypertrophy |
| activation of protein kinase B activity |
| negative regulation of interleukin-1 production |
| positive regulation of cardiac muscle tissue growth |
| regulation of amyloid precursor protein catabolic process |
| phosphatidylinositol 3-kinase signaling |
| positive regulation of vascular smooth muscle cell proliferation |
| regulation of calcineurin-mediated signaling |
| regulation of calcineurin-NFAT signaling cascade |
| skeletal muscle tissue regeneration |
| myoblast differentiation |
| regulation of glycogen metabolic process |
| regulation of cardiac muscle cell differentiation |
| regulation of activated T cell proliferation |
| positive regulation of smooth muscle cell migration |
| regulation of polysaccharide biosynthetic process |
| negative regulation of muscle cell apoptotic process |
| positive regulation of embryonic development |
| positive regulation of glucose import |
| positive regulation of heart growth |
| protein kinase B signaling |
| positive regulation of glucose metabolic process |
| cellular response to amyloid-beta |
| regulation of glycoprotein biosynthetic process |
| positive regulation of calcium-mediated signaling |
| regulation of polysaccharide metabolic process |
| positive regulation of glucose transmembrane transport |
| positive regulation of cardiac muscle tissue development |
| regulation of glycoprotein metabolic process |
| positive regulation of nucleotide metabolic process |
| positive regulation of ATP metabolic process |
| positive regulation of purine nucleotide metabolic process |
| positive regulation of organ growth |
| regulation of release of cytochrome c from mitochondria |
| bone mineralization |
| response to amyloid-beta |
| positive regulation of fibroblast proliferation |
| regulation of cardiocyte differentiation |
| regulation of vascular smooth muscle cell proliferation |
| regulation of transcription regulatory region DNA binding |
| positive regulation of mitotic nuclear division |
| negative regulation of mitochondrion organization |
| regulation of glucose import |
| positive regulation of DNA binding |
| regulation of cardiac muscle hypertrophy |
| negative regulation of reproductive process |
| myotube differentiation |
| positive regulation of osteoblast differentiation |
| positive regulation of cellular carbohydrate metabolic process |
| regulation of cardiac muscle tissue growth |
| positive regulation of striated muscle cell differentiation |
| negative regulation of tumor necrosis factor production |
| regulation of muscle hypertrophy |
| regulation of smooth muscle cell migration |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| tissue regeneration |
| positive regulation of Ras protein signal transduction |
| regulation of heart growth |
| regulation of multicellular organism growth |
| positive regulation of nuclear division |
| proteoglycan biosynthetic process |
| platelet alpha granule lumen |
| regulation of muscle cell apoptotic process |
| positive regulation of tyrosine phosphorylation of STAT protein |
| positive regulation of muscle organ development |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle tissue development |
| phosphatidylinositol-mediated signaling |
| positive regulation of small GTPase mediated signal transduction |
| regulation of glucose transmembrane transport |
| inositol lipid-mediated signaling |
| primary alcohol metabolic process |
| regulation of cardiac muscle tissue development |
| regulation of glycolytic process |
| positive regulation of carbohydrate metabolic process |
| regulation of tyrosine phosphorylation of STAT protein |
| regulation of interleukin-1 beta production |
| regulation of fibroblast proliferation |
| positive regulation of ossification |
| positive regulation of receptor signaling pathway via JAK-STAT |
| regulation of muscle adaptation |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of smooth muscle cell proliferation |
| positive regulation of muscle cell differentiation |
| regulation of carbohydrate catabolic process |
| positive regulation of receptor signaling pathway via STAT |
| proteoglycan metabolic process |
| biomineralization |
| biomineral tissue development |
| regulation of organ growth |
| positive regulation of T cell proliferation |
| regulation of carbohydrate biosynthetic process |
| regulation of interleukin-1 production |
| regulation of calcium-mediated signaling |
| hormone activity |
| regulation of striated muscle cell differentiation |
| negative regulation of extrinsic apoptotic signaling pathway |
| response to heat |
| regulation of osteoblast differentiation |
| regulation of glucose metabolic process |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of phosphatidylinositol 3-kinase signaling |
| regulation of ATP metabolic process |
| regulation of DNA binding |
| regulation of embryonic development |
| platelet degranulation |
| regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| integrin binding |
| regulation of striated muscle tissue development |
| regulation of smooth muscle cell proliferation |
| regulation of receptor signaling pathway via STAT |
| anatomical structure maturation |
| striated muscle cell development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| maintenance of cell number |
| negative regulation of inflammatory response |
| positive regulation of leukocyte proliferation |
| positive regulation of small molecule metabolic process |
| regulation of cellular carbohydrate metabolic process |
| negative regulation of cellular amide metabolic process |
| regulation of tumor necrosis factor production |
| muscle cell development |
| positive regulation of mitotic cell cycle |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of muscle cell differentiation |
| regulation of extrinsic apoptotic signaling pathway |
| activation of MAPK activity |
| regeneration |
| regulation of T cell proliferation |
| regulation of generation of precursor metabolites and energy |
| regulation of reproductive process |
| growth factor activity |
| positive regulation of cell growth |
| regulation of mitotic nuclear division |
| positive regulation of developmental growth |
| response to temperature stimulus |
| protein stabilization |
| positive regulation of binding |
| regulation of mitochondrion organization |
| positive regulation of epithelial cell proliferation |
| regulation of ossification |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of nuclear division |
| bone development |
| striated muscle cell differentiation |
| positive regulation of T cell activation |
| positive regulation of transmembrane transport |
| regulation of carbohydrate metabolic process |
| negative regulation of defense response |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| negative regulation of multi-organism process |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of leukocyte proliferation |
| negative regulation of apoptotic signaling pathway |
| regulation of muscle system process |
| developmental maturation |
| regulation of Ras protein signal transduction |
| muscle cell differentiation |
| Ras protein signal transduction |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| positive regulation of growth |
| positive regulation of MAP kinase activity |
| ossification |
| positive regulation of protein secretion |
| negative regulation of cytokine production |
| positive regulation of cell cycle process |
| regulation of protein stability |
| positive regulation of peptide secretion |
| muscle organ development |
| regulation of leukocyte cell-cell adhesion |
| muscle system process |
| alcohol metabolic process |
| regulation of T cell activation |
| small GTPase mediated signal transduction |
| glycoprotein biosynthetic process |
| cellular response to peptide |
| activation of protein kinase activity |
| regulation of developmental growth |
| regulation of epithelial cell proliferation |
| negative regulation of cell development |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of small GTPase mediated signal transduction |
| positive regulation of lymphocyte activation |
| negative regulation of response to external stimulus |
| positive regulation of cellular catabolic process |
| MAPK cascade |
| negative regulation of organelle organization |
| regulation of binding |
| positive regulation of cell cycle |
| glycoprotein metabolic process |
| developmental growth |
| growth |
| signal transduction by protein phosphorylation |
| regulation of apoptotic signaling pathway |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| regulation of cellular amide metabolic process |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| regulation of cell growth |
| positive regulation of protein transport |
| regulation of small molecule metabolic process |
| positive regulation of catabolic process |
| positive regulation of secretion |
| organic hydroxy compound metabolic process |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| response to peptide |
| muscle structure development |
| wound healing |
| skeletal system development |
| regulation of peptide secretion |
| drug metabolic process |
| positive regulation of cell migration |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cell motility |
| monocarboxylic acid metabolic process |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| positive regulation of locomotion |
| cell population proliferation |
| regulation of transmembrane transport |
| response to wounding |
| positive regulation of kinase activity |
| regulation of system process |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| carbohydrate derivative biosynthetic process |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| regulation of cell activation |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| regulation of growth |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulated exocytosis |
| negative regulation of cellular component organization |
| regulation of protein transport |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of cell cycle process |
| regulation of defense response |
| regulation of multi-organism process |
| exocytosis |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of cellular catabolic process |
| regulation of cell migration |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| negative regulation of cell death |
| regulation of catabolic process |
| regulation of cellular component movement |
| response to organonitrogen compound |
| oxoacid metabolic process |
| secretion by cell |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| regulation of protein localization |
| carbohydrate derivative metabolic process |
| export from cell |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell activation |
| response to nitrogen compound |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| phosphorylation |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6132
- Expression level (log2 read counts): 2.62
Expression Distribution
IGF1 Expression in NALM6 Cells: 2.62
