IGFALS

Gene Information
  • Official Symbol: IGFALS
  • Official Name: insulin like growth factor binding protein acid labile subunit
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 3483
  • UniProt: P35858
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
  • UniProt Summary: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 3447
  • Expression level (log2 read counts): -3.08

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1