IGFBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= IGFBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IGFBP1
  * **<color #00a2e8>Official Name</color>**: insulin like growth factor binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3484|3484]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08833|P08833]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IGFBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IGFBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. {ECO:0000269|PubMed:15972819}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IGFBP|
|Thyroglobulin 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|insulin-like growth factor II binding|
|PERK-mediated unfolded protein response|
|insulin-like growth factor I binding|
|insulin-like growth factor binding|
|regulation of insulin-like growth factor receptor signaling pathway|
|ER-nucleus signaling pathway|
|tissue regeneration|
|insulin receptor signaling pathway|
|endoplasmic reticulum unfolded protein response|
|cellular response to unfolded protein|
|cellular response to topologically incorrect protein|
|regeneration|
|cellular response to insulin stimulus|
|response to unfolded protein|
|positive regulation of cell growth|
|negative regulation of canonical Wnt signaling pathway|
|response to topologically incorrect protein|
|negative regulation of Wnt signaling pathway|
|response to insulin|
|response to endoplasmic reticulum stress|
|positive regulation of growth|
|cellular response to peptide hormone stimulus|
|aging|
|regulation of canonical Wnt signaling pathway|
|endoplasmic reticulum lumen|
|cellular response to peptide|
|signaling receptor binding|
|regulation of Wnt signaling pathway|
|post-translational protein modification|
|developmental growth|
|response to peptide hormone|
|growth|
|regulation of cell growth|
|response to peptide|
|wound healing|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to wounding|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|regulation of growth|
|enzyme linked receptor protein signaling pathway|
|response to hormone|
|Golgi apparatus|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|negative regulation of response to stimulus|
|cellular response to stress|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.95|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.62|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.85|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|3|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.03|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.06|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.22|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|3.46|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.525|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11876
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IGFBP1 Expression in NALM6 Cells: -4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>