IGFBP1

Entrez Summary: N/A
UniProt Summary: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. {ECO:0000269|PubMed:15972819}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

IGFBP
Thyroglobulin 1

insulin-like growth factor II binding
PERK-mediated unfolded protein response
insulin-like growth factor I binding
insulin-like growth factor binding
regulation of insulin-like growth factor receptor signaling pathway
ER-nucleus signaling pathway
tissue regeneration
insulin receptor signaling pathway
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
cellular response to topologically incorrect protein
regeneration
cellular response to insulin stimulus
response to unfolded protein
positive regulation of cell growth
negative regulation of canonical Wnt signaling pathway
response to topologically incorrect protein
negative regulation of Wnt signaling pathway
response to insulin
response to endoplasmic reticulum stress
positive regulation of growth
cellular response to peptide hormone stimulus
aging
regulation of canonical Wnt signaling pathway
endoplasmic reticulum lumen
cellular response to peptide
signaling receptor binding
regulation of Wnt signaling pathway
post-translational protein modification
developmental growth
response to peptide hormone
growth
regulation of cell growth
response to peptide
wound healing
transmembrane receptor protein tyrosine kinase signaling pathway
response to wounding
cellular response to organonitrogen compound
cellular response to hormone stimulus
cellular response to nitrogen compound