IGFBP2

Entrez Summary: N/A
UniProt Summary: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. {ECO:0000269|PubMed:19081843}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.74
Geldanamycin 0.01μM R05 exp235	1.79

IGFBP
Thyroglobulin 1

insulin-like growth factor II binding
insulin-like growth factor I binding
positive regulation of activated T cell proliferation
response to lithium ion
regulation of insulin-like growth factor receptor signaling pathway
regulation of activated T cell proliferation
response to estrogen
positive regulation of T cell proliferation
response to retinoic acid
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
response to estradiol
positive regulation of leukocyte proliferation
response to glucocorticoid
regulation of T cell proliferation
response to corticosteroid
negative regulation of canonical Wnt signaling pathway
female pregnancy
positive regulation of T cell activation
regulation of lymphocyte proliferation
negative regulation of Wnt signaling pathway
regulation of mononuclear cell proliferation
multi-multicellular organism process
response to mechanical stimulus
response to nutrient
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
cytoplasmic vesicle
positive regulation of cell-cell adhesion
aging
regulation of canonical Wnt signaling pathway
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
apical plasma membrane
response to steroid hormone
signaling receptor binding
response to acid chemical
positive regulation of lymphocyte activation
regulation of Wnt signaling pathway
response to metal ion