IKBKAP [The Human Chemical-Genetic Interaction Map Project]

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======= IKBKAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELP1
  * **<color #00a2e8>Official Name</color>**: elongator complex protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8518|8518]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95163|O95163]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IKBKAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IKBKAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603722|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IKI3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphorylase kinase regulator activity|
|Elongator holoenzyme complex|
|tRNA wobble uridine modification|
|tRNA wobble base modification|
|transcription elongation factor complex|
|RNA polymerase II complex binding|
|transcription elongation from RNA polymerase II promoter|
|tRNA modification|
|DNA-templated transcription, elongation|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of protein kinase activity|
|regulation of cell migration|
|nucleolus|
|regulation of kinase activity|
|RNA processing|
|regulation of cell motility|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|regulation of protein phosphorylation|
|protein-containing complex assembly|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.94|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.11|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.38|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.52|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ctu2|CTU2]]|0.59|
|[[:human genes:d:dph3|DPH3]]|0.582|
|[[:human genes:e:elp3|ELP3]]|0.58|
|[[:human genes:e:elp6|ELP6]]|0.563|
|[[:human genes:k:kti12|KTI12]]|0.529|
|[[:human genes:m:mocs3|MOCS3]]|0.528|
|[[:human genes:c:ctu1|CTU1]]|0.52|
|[[:human genes:u:urm1|URM1]]|0.506|
|[[:human genes:e:elp2|ELP2]]|0.5|
|[[:human genes:n:nr2c2ap|NR2C2AP]]|0.494|
|[[:human genes:e:elp4|ELP4]]|0.468|
|[[:human genes:e:elp5|ELP5]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 539/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|16/28|
|blood|19/28|
|bone|21/25|
|breast|21/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|7/15|
|kidney|19/21|
|liver|14/20|
|lung|59/75|
|lymphocyte|8/14|
|ovary|21/26|
|pancreas|21/24|
|peripheral nervous system|12/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|6/7|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|22/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1247
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IKBKAP Expression in NALM6 Cells: 7.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>