IKBKAP

Entrez Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
UniProt Summary: May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	1.94
MS023 7μM R03 exp135	2.11
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.38
Hippuristanol 0.12μM R08 exp488	2.52
MS023 2μM R03 exp134	2.71

Global Fraction of Cell Lines Where Essential: 539/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	16/28
blood	19/28
bone	21/25
breast	21/33
central nervous system	49/56
cervix	4/4
colorectal	13/17
esophagus	10/13
fibroblast	1/1
gastric	7/15
kidney	19/21
liver	14/20
lung	59/75
lymphocyte	8/14
ovary	21/26
pancreas	21/24
peripheral nervous system	12/16
plasma cell	5/15
prostate	1/1
skin	21/24
soft tissue	6/7
thyroid	1/2
upper aerodigestive	18/22
urinary tract	22/29
uterus	4/5

Expression Distribution

phosphorylase kinase regulator activity
Elongator holoenzyme complex
tRNA wobble uridine modification
tRNA wobble base modification
transcription elongation factor complex
RNA polymerase II complex binding
transcription elongation from RNA polymerase II promoter
tRNA modification
DNA-templated transcription, elongation
tRNA processing
RNA modification
tRNA metabolic process
ncRNA processing
ncRNA metabolic process
transcription by RNA polymerase II
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of protein kinase activity
regulation of cell migration
nucleolus
regulation of kinase activity
RNA processing
regulation of cell motility
protein phosphorylation
regulation of transferase activity
regulation of locomotion
regulation of cellular component movement
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
phosphorylation
organic cyclic compound biosynthetic process
regulation of protein phosphorylation
protein-containing complex assembly
regulation of phosphorylation