IL17RA

Gene Information

Official Symbol: IL17RA
Official Name: interleukin 17 receptor A
Aliases and Previous Symbols: N/A
Entrez ID: 23765
UniProt: Q96F46
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014].
UniProt Summary: Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971). {ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:9367539}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8248
Expression level (log2 read counts): 6.14

Expression Distribution

fibroblast activation
positive regulation of interleukin-23 production
positive regulation of interleukin-13 secretion
positive regulation of interleukin-5 secretion
interleukin-17 receptor activity
interleukin-17-mediated signaling pathway
regulation of interleukin-23 production
cellular response to interleukin-17
regulation of interleukin-5 secretion
response to interleukin-17
regulation of interleukin-13 secretion
positive regulation of interleukin-5 production
positive regulation of interleukin-13 production
positive regulation of cytokine production involved in inflammatory response
regulation of interleukin-13 production
regulation of interleukin-5 production
defense response to fungus
regulation of cytokine production involved in inflammatory response
response to fungus
granulocyte chemotaxis
granulocyte migration
myeloid leukocyte migration
positive regulation of inflammatory response
positive regulation of cytokine secretion
leukocyte chemotaxis
regulation of cytokine secretion
cell chemotaxis
positive regulation of protein secretion
positive regulation of peptide secretion
signaling receptor binding
regulation of inflammatory response
leukocyte migration
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of cytokine production
positive regulation of establishment of protein localization
regulation of protein secretion
positive regulation of defense response
regulation of peptide secretion