IL1R2

Gene Information

Official Symbol: IL1R2
Official Name: interleukin 1 receptor type 2
Aliases and Previous Symbols: N/A
Entrez ID: 7850
UniProt: P27930
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8879
Expression level (log2 read counts): -1.2

Expression Distribution

negative regulation of interleukin-1 alpha secretion
interleukin-1, type II, blocking receptor activity
negative regulation of interleukin-1 alpha production
regulation of interleukin-1 alpha secretion
negative regulation of interleukin-1-mediated signaling pathway
regulation of interleukin-1 alpha production
interleukin-1 binding
interleukin-1 receptor activity
regulation of interleukin-1-mediated signaling pathway
negative regulation of cytokine production involved in inflammatory response
negative regulation of interleukin-1 secretion
negative regulation of protein maturation
negative regulation of interleukin-1 production
negative regulation of protein processing
regulation of cytokine production involved in inflammatory response
regulation of interleukin-1 secretion
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
regulation of protein processing
regulation of protein maturation
negative regulation of cytokine secretion
regulation of interleukin-1 production
interleukin-1-mediated signaling pathway
negative regulation of protein secretion
negative regulation of inflammatory response
negative regulation of peptide secretion
regulation of cytokine-mediated signaling pathway
cellular response to interleukin-1
regulation of response to cytokine stimulus
negative regulation of protein transport
negative regulation of establishment of protein localization
response to interleukin-1
negative regulation of secretion by cell
regulation of cytokine secretion
negative regulation of defense response
negative regulation of secretion
negative regulation of cytokine production
regulation of inflammatory response
negative regulation of proteolysis
negative regulation of response to external stimulus