IL1RL2 [The Human Chemical-Genetic Interaction Map Project]

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======= IL1RL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL1RL2
  * **<color #00a2e8>Official Name</color>**: interleukin 1 receptor like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8808|8808]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HB29|Q9HB29]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL1RL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL1RL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7, ECO:0000269|PubMed:11466363}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-1, type I, activating receptor activity|
|interleukin-1 receptor activity|
|cellular defense response|
|positive regulation of T cell differentiation|
|positive regulation of lymphocyte differentiation|
|positive regulation of interleukin-6 production|
|interleukin-1-mediated signaling pathway|
|regulation of T cell differentiation|
|regulation of interleukin-6 production|
|positive regulation of leukocyte differentiation|
|regulation of lymphocyte differentiation|
|cellular response to interleukin-1|
|positive regulation of hemopoiesis|
|response to interleukin-1|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of inflammatory response|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|inflammatory response|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|defense response to other organism|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of response to stress|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.43|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.85|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.74|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.73|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.86|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13027
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL1RL2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>