IL1RL2

Entrez Summary: N/A
UniProt Summary: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7, ECO:0000269|PubMed:11466363}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

interleukin-1, type I, activating receptor activity
interleukin-1 receptor activity
cellular defense response
positive regulation of T cell differentiation
positive regulation of lymphocyte differentiation
positive regulation of interleukin-6 production
interleukin-1-mediated signaling pathway
regulation of T cell differentiation
regulation of interleukin-6 production
positive regulation of leukocyte differentiation
regulation of lymphocyte differentiation
cellular response to interleukin-1
positive regulation of hemopoiesis
response to interleukin-1
positive regulation of T cell activation
positive regulation of leukocyte cell-cell adhesion
positive regulation of cell-cell adhesion
regulation of leukocyte differentiation
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
regulation of inflammatory response
positive regulation of lymphocyte activation
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
positive regulation of cell activation
positive regulation of cytokine production
regulation of hemopoiesis
inflammatory response
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
cytokine-mediated signaling pathway
regulation of cell adhesion
regulation of cytokine production
regulation of defense response
innate immune response
defense response to other organism
positive regulation of cell differentiation
cellular response to cytokine stimulus