IL1RN [The Human Chemical-Genetic Interaction Map Project]

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======= IL1RN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IL1RN
  * **<color #00a2e8>Official Name</color>**: interleukin 1 receptor antagonist
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3557|3557]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18510|P18510]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IL1RN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IL1RN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147679|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. {ECO:0000269|PubMed:7775431}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-1 type I receptor antagonist activity|
|interleukin-1 type II receptor antagonist activity|
|interleukin-1, type I receptor binding|
|interleukin-1, type II receptor binding|
|interleukin-1 receptor antagonist activity|
|negative regulation of interleukin-1-mediated signaling pathway|
|regulation of interleukin-1-mediated signaling pathway|
|negative regulation of heterotypic cell-cell adhesion|
|regulation of cell-cell adhesion involved in gastrulation|
|interleukin-1 receptor binding|
|regulation of heterotypic cell-cell adhesion|
|regulation of gastrulation|
|insulin secretion|
|peptide hormone secretion|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|hormone secretion|
|hormone transport|
|neutrophil chemotaxis|
|granulocyte chemotaxis|
|neutrophil migration|
|positive regulation of interleukin-6 production|
|interleukin-1-mediated signaling pathway|
|granulocyte migration|
|myeloid leukocyte migration|
|regulation of embryonic development|
|positive regulation of JNK cascade|
|regulation of interleukin-6 production|
|response to glucocorticoid|
|leukocyte chemotaxis|
|protein secretion|
|establishment of protein localization to extracellular region|
|response to corticosteroid|
|regulation of cytokine-mediated signaling pathway|
|protein localization to extracellular region|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|signal release|
|cytokine activity|
|peptide secretion|
|cellular response to interleukin-1|
|negative regulation of cell-cell adhesion|
|regulation of response to cytokine stimulus|
|cellular response to lipopolysaccharide|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|cellular response to molecule of bacterial origin|
|response to interleukin-1|
|cell chemotaxis|
|cellular response to biotic stimulus|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of cell adhesion|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|leukocyte migration|
|regulation of cell-cell adhesion|
|positive regulation of cytokine production|
|inflammatory response|
|cellular response to lipid|
|regulation of hormone levels|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|cell migration|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to cytokine|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|peptide transport|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|amide transport|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17070
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IL1RN Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>