IL1RN

Entrez Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016].
UniProt Summary: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. {ECO:0000269|PubMed:7775431}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

interleukin-1 type I receptor antagonist activity
interleukin-1 type II receptor antagonist activity
interleukin-1, type I receptor binding
interleukin-1, type II receptor binding
interleukin-1 receptor antagonist activity
negative regulation of interleukin-1-mediated signaling pathway
regulation of interleukin-1-mediated signaling pathway
negative regulation of heterotypic cell-cell adhesion
regulation of cell-cell adhesion involved in gastrulation
interleukin-1 receptor binding
regulation of heterotypic cell-cell adhesion
regulation of gastrulation
insulin secretion
peptide hormone secretion
negative regulation of cytokine-mediated signaling pathway
negative regulation of response to cytokine stimulus
hormone secretion
hormone transport
neutrophil chemotaxis
granulocyte chemotaxis
neutrophil migration
positive regulation of interleukin-6 production
interleukin-1-mediated signaling pathway
granulocyte migration
myeloid leukocyte migration
regulation of embryonic development
positive regulation of JNK cascade
regulation of interleukin-6 production
response to glucocorticoid
leukocyte chemotaxis
protein secretion
establishment of protein localization to extracellular region
response to corticosteroid
regulation of cytokine-mediated signaling pathway
protein localization to extracellular region
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
signal release
cytokine activity
peptide secretion