IL21R
Gene Information
- Official Symbol: IL21R
- Official Name: interleukin 21 receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 50615
- UniProt: Q9HBE5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010].
- UniProt Summary: This is a receptor for interleukin-21.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8024
- Expression level (log2 read counts): 5.39
IL21R Expression in NALM6 Cells: 5.39
