IMMP2L

Entrez Summary: This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. {ECO:0000269|PubMed:15814844}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebellum vasculature development
mitochondrial inner membrane peptidase complex
protein processing involved in protein targeting to mitochondrion
mitochondrial protein processing
signal peptide processing
ovulation
superoxide metabolic process
ovarian follicle development
protein targeting to mitochondrion
serine-type peptidase activity
establishment of protein localization to mitochondrion
protein localization to mitochondrion
peptidase activity
female gonad development
development of primary female sexual characteristics
mitochondrial respiratory chain complex assembly
female sex differentiation
respiratory electron transport chain
reactive oxygen species metabolic process
female gamete generation
protein processing
cellular respiration
electron transport chain
gonad development
mitochondrial transport
development of primary sexual characteristics
protein maturation
energy derivation by oxidation of organic compounds
sex differentiation
protein targeting
blood circulation
circulatory system process
generation of precursor metabolites and energy
reproductive structure development
reproductive system development
establishment of protein localization to organelle
mitochondrion organization
vasculature development
cardiovascular system development
peptide metabolic process