INTU [The Human Chemical-Genetic Interaction Map Project]

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======= INTU =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTU
  * **<color #00a2e8>Official Name</color>**: inturned planar cell polarity protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27152|27152]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULD6|Q9ULD6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=INTU&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20INTU|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). {ECO:0000250|UniProtKB:Q059U7, ECO:0000250|UniProtKB:Q2I0E5, ECO:0000305|PubMed:27158779}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of keratinocyte proliferation|
|negative regulation of cell division|
|spinal cord dorsal/ventral patterning|
|motile cilium assembly|
|establishment of planar polarity|
|establishment of tissue polarity|
|spinal cord patterning|
|hair follicle morphogenesis|
|epidermis morphogenesis|
|positive regulation of smoothened signaling pathway|
|regulation of keratinocyte proliferation|
|morphogenesis of a polarized epithelium|
|non-motile cilium assembly|
|embryonic digit morphogenesis|
|hair follicle development|
|skin epidermis development|
|molting cycle process|
|hair cycle process|
|regulation of smoothened signaling pathway|
|dorsal/ventral pattern formation|
|molting cycle|
|hair cycle|
|motile cilium|
|spinal cord development|
|negative regulation of epithelial cell proliferation|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|ciliary basal body|
|appendage morphogenesis|
|limb morphogenesis|
|neural tube development|
|regulation of cell division|
|limb development|
|appendage development|
|regulation of ossification|
|keratinocyte differentiation|
|epidermal cell differentiation|
|regionalization|
|regulation of epithelial cell proliferation|
|cilium assembly|
|cilium organization|
|skin development|
|epidermis development|
|morphogenesis of an epithelium|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|tissue morphogenesis|
|embryonic morphogenesis|
|cell surface|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|organelle assembly|
|tube development|
|embryo development|
|central nervous system development|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13575
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='INTU Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>