INTU

Entrez Summary: N/A
UniProt Summary: Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). {ECO:0000250|UniProtKB:Q059U7, ECO:0000250|UniProtKB:Q2I0E5, ECO:0000305|PubMed:27158779}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of keratinocyte proliferation
negative regulation of cell division
spinal cord dorsal/ventral patterning
motile cilium assembly
establishment of planar polarity
establishment of tissue polarity
spinal cord patterning
hair follicle morphogenesis
epidermis morphogenesis
positive regulation of smoothened signaling pathway
regulation of keratinocyte proliferation
morphogenesis of a polarized epithelium
non-motile cilium assembly
embryonic digit morphogenesis
hair follicle development
skin epidermis development
molting cycle process
hair cycle process
regulation of smoothened signaling pathway
dorsal/ventral pattern formation
molting cycle
hair cycle
motile cilium
spinal cord development
negative regulation of epithelial cell proliferation
embryonic appendage morphogenesis
embryonic limb morphogenesis
ciliary basal body
appendage morphogenesis
limb morphogenesis
neural tube development
regulation of cell division
limb development
appendage development
regulation of ossification
keratinocyte differentiation
epidermal cell differentiation
regionalization
regulation of epithelial cell proliferation
cilium assembly