IQSEC1

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. {ECO:0000269|PubMed:11226253, ECO:0000269|PubMed:16461286, ECO:0000269|PubMed:24058294}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of keratinocyte migration
regulation of keratinocyte migration
regulation of ARF protein signal transduction
ARF guanyl-nucleotide exchange factor activity
positive regulation of adherens junction organization
regulation of adherens junction organization
positive regulation of epithelial cell migration
lipid binding
regulation of epithelial cell migration
regulation of Ras protein signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
regulation of GTPase activity
actin cytoskeleton organization
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
actin filament-based process
intracellular membrane-bounded organelle
positive regulation of hydrolase activity
regulation of cell migration
nucleolus
regulation of cell motility
regulation of locomotion
regulation of cellular component movement
cytoskeleton organization
positive regulation of cellular component organization
regulation of hydrolase activity
positive regulation of catalytic activity
positive regulation of multicellular organismal process
positive regulation of molecular function
regulation of intracellular signal transduction
membrane