IRAK2 [The Human Chemical-Genetic Interaction Map Project]

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======= IRAK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IRAK2
  * **<color #00a2e8>Official Name</color>**: interleukin 1 receptor associated kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3656|3656]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43187|O43187]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IRAK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IRAK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603304|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. {ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:9374458}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Death|
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|toll-like receptor 9 signaling pathway|
|nucleotide-binding oligomerization domain containing signaling pathway|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|MyD88-dependent toll-like receptor signaling pathway|
|lipopolysaccharide-mediated signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway|
|I-kappaB kinase/NF-kappaB signaling|
|JNK cascade|
|negative regulation of NF-kappaB transcription factor activity|
|interleukin-1-mediated signaling pathway|
|toll-like receptor signaling pathway|
|stress-activated MAPK cascade|
|pattern recognition receptor signaling pathway|
|stress-activated protein kinase signaling cascade|
|positive regulation of NF-kappaB transcription factor activity|
|activation of MAPK activity|
|negative regulation of DNA-binding transcription factor activity|
|intracellular receptor signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|cellular response to interleukin-1|
|regulation of response to cytokine stimulus|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|response to interleukin-1|
|endosome membrane|
|cellular response to biotic stimulus|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|positive regulation of response to biotic stimulus|
|protein serine/threonine kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|regulation of innate immune response|
|positive regulation of defense response|
|protein heterodimerization activity|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|protein phosphorylation|
|regulation of transferase activity|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14328
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IRAK2 Expression in NALM6 Cells: 0.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>