IRAK2

Gene Information

Official Symbol: IRAK2
Official Name: interleukin 1 receptor associated kinase 2
Aliases and Previous Symbols: N/A
Entrez ID: 3656
UniProt: O43187
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. {ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:9374458}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14328
Expression level (log2 read counts): 0.58

Expression Distribution

Death
Pkinase Tyr
Pkinase

toll-like receptor 9 signaling pathway
nucleotide-binding oligomerization domain containing signaling pathway
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
lipopolysaccharide-mediated signaling pathway
cytoplasmic pattern recognition receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
JNK cascade
negative regulation of NF-kappaB transcription factor activity
interleukin-1-mediated signaling pathway
toll-like receptor signaling pathway
stress-activated MAPK cascade
pattern recognition receptor signaling pathway
stress-activated protein kinase signaling cascade
positive regulation of NF-kappaB transcription factor activity
activation of MAPK activity
negative regulation of DNA-binding transcription factor activity
intracellular receptor signaling pathway
regulation of cytokine-mediated signaling pathway
cellular response to interleukin-1
regulation of response to cytokine stimulus
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
response to interleukin-1
endosome membrane
cellular response to biotic stimulus
innate immune response-activating signal transduction
activation of innate immune response
positive regulation of DNA-binding transcription factor activity
positive regulation of MAP kinase activity
response to lipopolysaccharide
response to molecule of bacterial origin
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
positive regulation of innate immune response
regulation of MAP kinase activity
positive regulation of response to biotic stimulus
protein serine/threonine kinase activity
MAPK cascade
signal transduction by protein phosphorylation