ISM1

Entrez Summary: N/A
UniProt Summary: Acts as an angiogenesis inhibitor. {ECO:0000250|UniProtKB:A2ATD1}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TSP 1
AMOP

negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
regulation of angiogenesis
regulation of vasculature development
negative regulation of developmental process
regulation of anatomical structure morphogenesis
negative regulation of multicellular organismal process
extracellular region