ITGA8

Gene Information

Official Symbol: ITGA8
Official Name: integrin subunit alpha 8
Aliases and Previous Symbols: N/A
Entrez ID: 8516
UniProt: P53708
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014].
UniProt Summary: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. {ECO:0000269|PubMed:12415008, ECO:0000269|PubMed:15721307}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3007
Expression level (log2 read counts): 0.93

Expression Distribution

FG-GAP
Integrin alpha2

integrin alpha8-beta1 complex
positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
dendritic spine membrane
smooth muscle tissue development
integrin complex
mesodermal cell differentiation
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of cellular response to transforming growth factor beta stimulus
smooth muscle cell differentiation
substrate adhesion-dependent cell spreading
mesoderm formation
mesoderm morphogenesis
apical part of cell
metanephros development
integrin-mediated signaling pathway
inner ear morphogenesis
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
formation of primary germ layer
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
memory
ear morphogenesis
mesoderm development
cell-matrix adhesion
perikaryon
gastrulation
cell-substrate adhesion
inner ear development
ear development
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
muscle cell differentiation
postsynaptic density
sensory organ morphogenesis
learning or memory
kidney development
regulation of cellular response to growth factor stimulus
renal system development
embryonic organ morphogenesis
muscle tissue development
cognition