JAG2

Entrez Summary: N/A
UniProt Summary: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Oligomycin-A 20μM R00 exp26	-1.9
CI-1040 9.5μM R08 exp472	1.82

epithelial cell apoptotic process involved in palatal shelf morphogenesis
gamma-delta T cell differentiation
inner ear receptor cell fate commitment
auditory receptor cell fate commitment
gamma-delta T cell activation
respiratory system process
epithelial cell fate commitment
apoptotic process involved in morphogenesis
thymic T cell selection
secondary palate development
inner ear auditory receptor cell differentiation
Notch binding
apoptotic process involved in development
epithelial cell apoptotic process
hair cell differentiation
T cell selection
respiratory gaseous exchange by respiratory system
negative regulation of Notch signaling pathway
neuroepithelial cell differentiation
T cell differentiation in thymus
inner ear receptor cell differentiation
positive regulation of Notch signaling pathway
mechanoreceptor differentiation
neuron fate commitment
odontogenesis of dentin-containing tooth
roof of mouth development
columnar/cuboidal epithelial cell differentiation
regulation of Notch signaling pathway
odontogenesis
Notch signaling pathway
T cell differentiation
morphogenesis of embryonic epithelium
growth factor activity
inner ear development
ear development
T cell activation
lymphocyte differentiation
cell fate commitment
epidermal cell differentiation
leukocyte differentiation