JPH4

Gene Information

Official Symbol: JPH4
Official Name: junctophilin 4
Aliases and Previous Symbols: N/A
Entrez ID: 84502
UniProt: Q96JJ6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4769
Expression level (log2 read counts): -3.13

Expression Distribution

junctional membrane complex
junctional sarcoplasmic reticulum membrane
calcium-release channel activity
regulation of store-operated calcium entry
regulation of ryanodine-sensitive calcium-release channel activity
smooth endoplasmic reticulum
dendritic shaft
neuromuscular process controlling balance
release of sequestered calcium ion into cytosol
negative regulation of sequestering of calcium ion
calcium ion transmembrane import into cytosol
calcium ion transport into cytosol
regulation of release of sequestered calcium ion into cytosol
regulation of calcium ion transmembrane transporter activity
cytosolic calcium ion transport
regulation of calcium-mediated signaling
regulation of calcium ion transport into cytosol
neuromuscular process
regulation of sequestering of calcium ion
learning
regulation of calcium ion transmembrane transport
regulation of cation channel activity
regulation of synaptic plasticity
calcium ion transmembrane transport
regulation of calcium ion transport
calcium ion transport
regulation of ion transmembrane transporter activity
learning or memory
regulation of transmembrane transporter activity
regulation of transporter activity
positive regulation of cytosolic calcium ion concentration
divalent metal ion transport
cognition
divalent inorganic cation transport
regulation of cytosolic calcium ion concentration
regulation of cation transmembrane transport
regulation of metal ion transport
cellular calcium ion homeostasis
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling