JSRP1

Entrez Summary: The protein encoded by this gene is involved in excitation-contraction coupling at the sarcoplasmic reticulum. The encoded protein can interact with CACNA1S, CACNB1, and calsequestrin to help regulate calcium influx and efflux in skeletal muscle. [provided by RefSeq, Jul 2012].
UniProt Summary: Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. {ECO:0000269|PubMed:22927026}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of ryanodine-sensitive calcium-release channel activity
skeletal muscle contraction
sarcoplasmic reticulum membrane
multicellular organismal movement
musculoskeletal movement
sarcoplasmic reticulum
regulation of release of sequestered calcium ion into cytosol
regulation of calcium ion transmembrane transporter activity
regulation of calcium-mediated signaling
regulation of calcium ion transport into cytosol
striated muscle contraction
regulation of sequestering of calcium ion
regulation of calcium ion transmembrane transport
regulation of cation channel activity
regulation of calcium ion transport
muscle contraction
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
muscle system process
regulation of cation transmembrane transport
regulation of metal ion transport
regulation of ion transmembrane transport
regulation of transmembrane transport
regulation of ion transport
regulation of cellular localization
regulation of intracellular signal transduction
regulation of transport
system process