KCNE1L

Gene Information

Official Symbol: KCNE5
Official Name: potassium voltage-gated channel subfamily E regulatory subunit 5
Aliases and Previous Symbols: N/A
Entrez ID: 23630
UniProt: Q9UJ90
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016].
UniProt Summary: Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. {ECO:0000269|PubMed:12324418}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18035
Expression level (log2 read counts): -1.13

Expression Distribution

negative regulation of potassium ion export across plasma membrane
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
regulation of atrial cardiac muscle cell membrane repolarization
regulation of potassium ion export across plasma membrane
negative regulation of delayed rectifier potassium channel activity
ventricular cardiac muscle cell membrane repolarization
negative regulation of voltage-gated potassium channel activity
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
membrane repolarization during ventricular cardiac muscle cell action potential
atrial cardiac muscle cell action potential
atrial cardiac muscle cell to AV node cell signaling
atrial cardiac muscle cell to AV node cell communication
potassium ion export across plasma membrane
membrane repolarization during cardiac muscle cell action potential
membrane repolarization during action potential
regulation of delayed rectifier potassium channel activity
cardiac muscle cell membrane repolarization
negative regulation of potassium ion transmembrane transporter activity
ventricular cardiac muscle cell action potential
membrane repolarization
regulation of ventricular cardiac muscle cell membrane repolarization
negative regulation of potassium ion transmembrane transport
regulation of cardiac muscle cell membrane repolarization
cell-cell signaling involved in cardiac conduction
negative regulation of potassium ion transport
delayed rectifier potassium channel activity
regulation of membrane repolarization
regulation of heart rate by cardiac conduction
positive regulation of potassium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
export across plasma membrane
potassium channel regulator activity
cardiac muscle cell contraction
negative regulation of cation channel activity
cell communication involved in cardiac conduction
positive regulation of potassium ion transport
cardiac muscle cell action potential
regulation of potassium ion transmembrane transporter activity
voltage-gated potassium channel activity
negative regulation of ion transmembrane transporter activity