KCNH6

Entrez Summary: N/A
UniProt Summary: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MK2206 4μM R08 exp504	-1.71
BI-2536 0.0042μM R03 exp95	1.94

voltage-gated potassium channel activity
potassium ion transmembrane transport
potassium ion transport
monovalent inorganic cation transport
regulation of membrane potential
regulation of ion transmembrane transport
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
regulation of ion transport
cation transport
ion transmembrane transport
transmembrane transport
ion transport
integral component of plasma membrane
regulation of transport