KCNIP2 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNIP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNIP2
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30819|30819]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NS61|Q9NS61]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNIP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNIP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604661|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ER retention sequence binding|
|positive regulation of potassium ion export across plasma membrane|
|clustering of voltage-gated potassium channels|
|A-type (transient outward) potassium channel activity|
|potassium channel complex|
|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|
|regulation of potassium ion export across plasma membrane|
|neuronal ion channel clustering|
|detection of calcium ion|
|potassium ion export across plasma membrane|
|positive regulation of voltage-gated potassium channel activity|
|membrane repolarization during cardiac muscle cell action potential|
|membrane repolarization during action potential|
|cardiac muscle cell membrane repolarization|
|membrane repolarization|
|positive regulation of potassium ion transmembrane transporter activity|
|neuron maturation|
|positive regulation of potassium ion transmembrane transport|
|export across plasma membrane|
|potassium channel regulator activity|
|positive regulation of potassium ion transport|
|cardiac muscle cell action potential|
|regulation of potassium ion transmembrane transporter activity|
|positive regulation of cation channel activity|
|regulation of potassium ion transmembrane transport|
|voltage-gated potassium channel complex|
|cardiac conduction|
|action potential|
|regulation of potassium ion transport|
|positive regulation of ion transmembrane transporter activity|
|protein N-terminus binding|
|positive regulation of transporter activity|
|ion channel binding|
|multicellular organismal signaling|
|anatomical structure maturation|
|positive regulation of cation transmembrane transport|
|response to calcium ion|
|positive regulation of ion transmembrane transport|
|cell maturation|
|potassium ion transmembrane transport|
|potassium ion transport|
|regulation of cation channel activity|
|positive regulation of transmembrane transport|
|developmental maturation|
|regulation of heart contraction|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|muscle system process|
|regulation of cation transmembrane transport|
|response to metal ion|
|regulation of metal ion transport|
|monovalent inorganic cation transport|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|synaptic signaling|
|regulation of ion transmembrane transport|
|detection of chemical stimulus|
|response to inorganic substance|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|detection of stimulus|
|regulation of ion transport|
|calcium ion binding|
|neuron development|
|cation transport|
|membrane organization|
|ion transmembrane transport|
|positive regulation of transport|
|neuron differentiation|
|export from cell|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of molecular function|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6027
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNIP2 Expression in NALM6 Cells: 0.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>